Immunotoxicology of JP-8 Jet Fuel: Mechanisms
Final performance rept. 1 Sep 2006-31 Mar 2008
ARIZONA UNIV TUCSON DEPT OF IMMUNOBIOLOGY AND PEDIATRICS
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Experiments were performed exposing mice to varying doses of either JP-8 or S-8 jet fuel for 1hday for 7 days, using the new exposure apparatus with in-line monitoring of jet fuel concentrations aerosol and vapor. Six controls, 6 JP-8 exposed and 6 S-8 exposed animals examined. There were no significant effect on body weight due to JP-8 or S-8 exposure, and no effect on immune cell viability from any immune organ due to JP-8 or S-8 exposure. There was a 53 decrease in Spleen weight due to S-8 exposure and a corresponding 40 decrease due to JP-8 exposure. There was a 36 decrease in Thymus weight due to S-8 exposure and a corresponding 60 decrease due to JP-8 exposure. There was a 64 decrease in Thymus cell numbers due to S-8 exposure and a corresponding 46 decrease due to JP-8 exposure. There was a 20 decrease in Spleen cell numbers due to JP-8 exposure only. No significant change in composition in any immune organ due to JP-8 or S-8 exposure. Both JP-8 and S-8 exposures using the new exposure chamber resulted in changes in immune function.
- Medicine and Medical Research