Accession Number:

ADA488538

Title:

Immunotoxicology of JP-8 Jet Fuel: Mechanisms

Descriptive Note:

Final performance rept. 1 Sep 2006-31 Mar 2008

Corporate Author:

ARIZONA UNIV TUCSON DEPT OF IMMUNOBIOLOGY AND PEDIATRICS

Personal Author(s):

• Harris, David T.
• Wang, J.
• Camacho, D.
• Badowski, M.
• Tsang, T.
• Witten, M.

Report Date:

2008-07-20

Pagination or Media Count:

7.0

Abstract:

Experiments were performed exposing mice to varying doses of either JP-8 or S-8 jet fuel for 1hday for 7 days, using the new exposure apparatus with in-line monitoring of jet fuel concentrations aerosol and vapor. Six controls, 6 JP-8 exposed and 6 S-8 exposed animals examined. There were no significant effect on body weight due to JP-8 or S-8 exposure, and no effect on immune cell viability from any immune organ due to JP-8 or S-8 exposure. There was a 53 decrease in Spleen weight due to S-8 exposure and a corresponding 40 decrease due to JP-8 exposure. There was a 36 decrease in Thymus weight due to S-8 exposure and a corresponding 60 decrease due to JP-8 exposure. There was a 64 decrease in Thymus cell numbers due to S-8 exposure and a corresponding 46 decrease due to JP-8 exposure. There was a 20 decrease in Spleen cell numbers due to JP-8 exposure only. No significant change in composition in any immune organ due to JP-8 or S-8 exposure. Both JP-8 and S-8 exposures using the new exposure chamber resulted in changes in immune function.

Descriptors:

• *IMMUNOLOGY
• *TOXICOLOGY
• *HISTOPATHOLOGY
• *JET ENGINE FUELS
• CONCENTRATION(COMPOSITION)
• EXPOSURE(PHYSIOLOGY)
• THYMUS
• CELLS(BIOLOGY)
• AEROSOLS
• BODY WEIGHT
• DOSAGE
• VIABILITY
• VAPORS
• SPLEEN

Subject Categories:

• Medicine and Medical Research
• Toxicology
• Fuels

Distribution Statement:

APPROVED FOR PUBLIC RELEASE