A Role for TACI in Prostate Neoplasia
Annual rept. 15 Dec 2004-14 Dec 2005
INDIANA UNIV AT INDIANAPOLIS SCHOOL OF MEDICINE
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This research study proposed that TNF-family growth factors, BAFF and APRIL, play a role in prostate cancer. The investigators hypothesis proposed that APRIL provides a proliferative signal to normal prostate epithelial cells by means of an unknown receptor. They postulated that TACI is an antagonist receptor that functions to regulate APRIL-mediated proliferation of cells by inducing apoptosis and thereby maintaining the normal glandular structure. The loss of TACI expression in prostate cells therefore conceivably results in an imbalance in homeostasis resulting in the aberrant accumulation of cells that become susceptible to transformation. Their hypothesis anticipated that the addition of APRIL would enhance cell growth whereas the addition of TACI-Ig would either reduce cell growth or induce apoptosis. This did not happen and they did not see any significant changes in the relative numbers of hyperdiploid cells as determined by propidium iodide flow cytometry. Because of the negative results, the study was terminated early and the grant relinquished. Dr. Von Bulow no longer works for Indiana University.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research