Site-Specific Differentiation of Fibroblasts in Normal and Scleroderma Skin
Annual rept. 1 Jun 2007-31 May 2008
LELAND STANFORD JUNIOR UNIV CA
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The results from year I of funding suggest that appropriate markers and technologies are in place for systematic investigation of the positional identity of fibroblasts both in normal and diseased tissues. Because long noncoding RNAs are the predominant position specific output of the HOX loci they may constitute excellent markers for testing the idea that scleroderma involves altered fibroblast positional identity.
- Anatomy and Physiology
- Medicine and Medical Research