ER/PR Status of the Originating Cell of ER-Negative Breast Cancer
Annual rept. 1 Apr 2007-31 Mar 2008
BAYLOR COLL OF MEDICINE HOUSTON TX
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The goal of this study is to test whether ER breast cancers arise from ER or ER mammary cells. We specifically hypothesize that ER is absent in the originating cell of ER-negative breast cancer. Although until now it has been technically difficult to test it, we have developed a unique mouse model based on the RCASTVA technology that allows us to trace the ER status of the cancer-originating cell. It is now possible to test this hypothesis in experimental mice.
- Anatomy and Physiology
- Medicine and Medical Research