Accession Number:

ADA488018

Title:

Molecular Solutions to Low Injuries Resulting from Battlefield Injuries. Addendum

Descriptive Note:

Annual rept. 15 May 2007-14 Apr 2008

Corporate Author:

SCHEPENS EYE RESEARCH INST BOSTON MA

Personal Author(s):

Report Date:

2008-05-01

Pagination or Media Count:

19.0

Abstract:

We hypothesize that targeted molecular intervention can preserve vision threatened by battlefield trauma-induced corneal and retinal inflammation, corneal and retinaoptic nerve apoptosis, ocular surface dry eye after refractive surgery, and retinal degeneration. We are studying the consequences of trauma-induced 1 corneal inflammation using a gene therapy approach of providing soluble Fas ligand to the cornea to determine if this ligand can suppress corneal inflammation in mice 2 retinal inflammation by examining if transforming growth factor-beta, thrombospondin, and somatostatin, in subretinal space, can suppress inflammation within retina secondary to autoimmune uveoretinitis and light-induced damage in mice 3 corneal cell death by apoptosis and promote regeneration by identifying the anti-apoptotic gene with the greatest capacity to suppress corneal cell apoptosis using mice 4 retinal cell death and regeneration by using mice to determine if systemic treatment with lithium chloride can prevent collateral damage to retinal neurons and promote optic nerve regeneration 5 dry eye by determining how to minimize dry eye after LASIK refractive surgery by developing new tests to predict pre-disposition to refractive surgery induced dry eye and 6 retinal injury by generating stem cell polymer composites.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE