Accession Number:

ADA488016

Title:

CXCL5 is a Novel Mediator of Prostate Cancer Proliferation and Migration/Invasion

Descriptive Note:

Final rept.

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

Report Date:

2008-06-01

Pagination or Media Count:

19.0

Abstract:

The primary concept driving this proposal is that CXCL5 may provide a link between aging and the development of malignant proliferative prostatic disease, and may act as a previously unrecognized growth factor that promotes prostate cancer cell proliferation and migrationinvasion. The major findings of these studies are that CXCL5 protein expression levels are significantly elevated in primary and metastatic prostate tumors, that CXCL5 induces prostate cancer cell proliferation, migration and invasion in vitro, and that CXCL5 activates both MAPK and PI3K signaling and stimulates gene transcription in both nontransformed and transformed prostate epithelial cells. These findings suggest that CXCL5 works at many levels to promote prostate tumor progression and metastasis. Moreover, CXCL5 may provide a non-steroidal therapeutic target useful towards the treatment of hormone refractory prostate cancers.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE