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Annexin II-Dependent Mechanism of Breast Cancer Progression

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Annual rept. 1 Jun 2007-31 May 2008

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Angiogenesis and metastasis are two processes that are central to the progression of cancer. As such, they have become important targets for the development of anti-cancer agents. Invasive and metastatic cancers of the breast are distinguished by their propensity of newly formed blood vessels neoangiogenesis. Neoangiogenesis is a significant independent prognostic indicator in early stage breast cancer 1. Delineating the molecular mechanisms of neoangiogenesis may provide new insights into the biology of breast cancer progression and metastasis and may provide novel prognostic and therapeutic tools. Recently, the plasminogen PLGplasmin PL system was demonstrated to play an important role in breast cancer progression and metastasis. Experimental studies in animal models combined with extensive clinicopathological data provide a compelling case indicating that proteins of PLGPL pathways play a key role in breast cancer progression and metastasis2. In this context, enzymes of the PLGPL pathway have been reported to have prognostic value in breast cancer and are associated with poor prognosis both for overall and disease free survival2. In fact these molecules have been associated with a high rate of relapse for patients with breast cancer Preliminary studies in animal model demonstrated that PLG gene deficient mice PLG-- display inhibition of tumor invasion, lymph node metastasis and angiogenesis supporting the idea that PL is required for angiogenesis, tumor growth and metastasis3. Despite established role in tumor angiogenesis, growth and metastasis it is still unclear.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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