CYP1B1, Oxidative Stress, and Inflammation in the Etiology of Ovarian Epithelial Cancer Using an Avian Model of Ovarian Carcinoma
Final rept. 28 Oct 2005-27 Oct 2007
ILLINOIS UNIV AT CHICAGO
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Ovarian cancer is the most lethal of the gynecological malignancies due to its late stage of detection. Research in ovarian cancer has been hampered by a lack of suitable animal models. With the exception of the laying hen, no other animal gets ovarian epithelial cancer analogous to the human disease. The study further validates the hen model of ovarian cancer. The results of the study demonstrate that cancer markers in the human disease are valid in the hen including PCNA, E and N-cadherin, and cytokeratin the histopathology of the human and chicken ovarian cancer are similar that Cyclooxygenase-1 COX-1 expression, an enzyme critical for inflammatory prostaglandin synthesis is up-regulated in both the chicken and human disease suggesting it may be molecular target for intervention DNA microarray studies identified critical pathways that may be important to the understanding the disease. CYP1B1 demonstrates high basal expression which appears to increase with age in the chicken ovary with no apparent further increase observed in cancer, in contrast to what has been reported in human ovarian cancer. The hen model may provide a system for large scale therapeutic intervention studies.
- Anatomy and Physiology
- Medicine and Medical Research