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Early Life Processes, Endocrine Mediators and Number of Susceptible Cells in Relation to Breast Cancer Risk

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Annual rept. 15 Mar 2007-14 Mar 2008

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To investigate the role of early life processes, endocrine mediators and number of susceptible cells on adult life breast cancer risk. Five interlinked component projects covering the spectrum from endometrial to adult life. Progress report Component projects 1 to 4 were officially launched July 2005. Component projects 5a and 5b were officially launched July 18, 2006. Tasks and subtasks to be performed were described in the submitted Statement of Work SOW. Subtasks 1a, 1b, 2a, 2b, 3a, 3b, 3c, 4a, 4b, 4c, 5a, 5b have been completed. Subtasks 1c, 2c, 2d, 3d, 4d, 5c, 5d are ongoing. Subtasks 3e, 4e, 5f and 5g have been initiated. Subtasks 6a, 6b and 6c are being implemented. a No substantial main effect of ESR1 and EGF on breast cancer risk, so that interaction with early life influences is unlikely CP3 b Differences in the estradiol serum concentrations between the Boston and Shanghai pregnant women have been found to persist even after adjusting for proxies of plasma volume expansion CP4. c Androgen levels have been found to be higher in cord blood samples from Chinese compared to Caucasian women, suggesting that elevated prenatal androgen exposure could mediate reductions in breast cancer risk CP4. d Collagen I substrate has been found to be essential for the formation of mammospheres from epithelial cells found in cord blood CP5. e Among term newborns with a normal-to-high birth weight, birth weight was found to be significantly positively associated with stem cell measurements, supporting a role of stem cell pool on cancer risk CP5.

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  • Medicine and Medical Research

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