Accession Number:

ADA486167

Title:

The Role of ABC Proteins in Drug Resistant Breast Cancer Cells

Descriptive Note:

Annual summary rept. 15 Mar 2006-14 Mar 2008

Corporate Author:

GEORGETOWN UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2008-04-01

Pagination or Media Count:

34.0

Abstract:

This predoctoral training grant, supported by the Department of Defense Breast Cancer Research Program BCRP of the Office of the Congressionally Directed Medical Research Programs CDMRP, aims to study the possible role of ABC transporters in pleitropic drug resistance, using a combination of molecular biological, biochemical, and biophysical methods. The second year of funding was spent working with a member of a drugmetabolite transporter superfamily called the Plasmodium falciparum Chloroquine Transporter PfCRT. While PfCRT is known to be the main molecular determinant of chloroquine resistance, there is only indirect proof of its interaction with the drug. Therefore, I have employed a methodology commonly applied to drug resistance proteins such as human P-glycoprotein and labeled PfCRT with a photoaffinity drug analogue. A manuscript is currently in preparation detailing my results.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE