Accession Number:

ADA485733

Title:

Control of Growth Within Drosophila Peripheral Nerves by Ras and Protein Kinase A

Descriptive Note:

Annual rept. 27 Jan 2007-26 Jan 2008

Corporate Author:

RICE UNIV HOUSTON TX

Personal Author(s):

• Stern, Michael

Report Date:

2008-02-01

Pagination or Media Count:

40.0

Abstract:

The long term goals of this research are to understand the mechanisms by whichNF1 and its partners control growth using the Drosophila peripheral nerve as our assay system. This system is advantageous because we can apply a number of powerful molecular genetic methodologies that are not available in other systems. Our major findings were generated from aim 4. We reported after year2 that Ras nonautonomously activates perineurial glial growth via PI3 Kinase, Akt and FOXO published in the Journal of Neuroscience in 2007. Second, were port preliminary evidence that pushover push acts in the glia to regulate perineurial glial growth, but in the neuron to regulate excitability. Third, we report that activation of the Tor pathway is necessary but not sufficient to increase perineurial glial growth. Fourth, we report that the metabotropic glutamate receptor regulates neuronal growth and excitability via PI3K.

Descriptors:

• *NERVE CELLS
• *DROSOPHILA
• MOLECULES
• GLUTAMIC ACID
• PROTEINS
• SALTS
• ASSAYING
• GENETICS
• NERVES
• SENSE ORGANS
• GROWTH(PHYSIOLOGY)
• PHOSPHORUS TRANSFERASES
• PERIPHERAL NERVOUS SYSTEM
• METHODOLOGY
• ACTIVATION

Subject Categories:

• Genetic Engineering and Molecular Biology
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE