Accession Number:
ADA484925
Title:
Human Bone Matrix Changes During Deep Saturation Dives
Descriptive Note:
Technical rept. 1997-1999
Corporate Author:
NAVAL SUBMARINE MEDICAL RESEARCH LAB GROTON CT
Personal Author(s):
Report Date:
2008-08-08
Pagination or Media Count:
28.0
Abstract:
In 1999, 8 U.S Navy divers underwent a dry hyperbaric chamber dive to 305 meters of seawater msw. Measurements of serum osteocalcin and urine crosslinked N-telopeptide were made at baseline, 305 msw, and immediately after surfacing. The bone marker levels for the divers and volunteers were analyzed by repeated-measures ANOVA, with planned comparisons made between markers and dive phase. The data for the 1999 dive revealed a significant decrease in urine Ntx, with no change in serum osteocalcin. Data from the 1999 dive were combined in a Meta-analysis with Ntx and osteocalcin measurements taken during two similar 305 msw dive profiles conducted in 1997 and 1998. The Meta-analysis revealed a reduction in serum osteocalcin following saturation at 305 msw but no significant change in Ntx at depth. Taken together these studies may have identified a response of bone metabolism to changes in ambient pressure, however questions still remain as to whether blood sample handlingdecompression procedures during the 1998 dive affected the Meta-analysis results for osteocalcin.
Descriptors:
Subject Categories:
- Stress Physiology