Accession Number:

ADA482999

Title:

Characterization of MHC-Related Volatile Organic Compounds in Heterologous Expression Systems: Role of Infection in Odor Compound Generation

Descriptive Note:

Final rept. 1 Jul 2006-30 Jun 2007

Corporate Author:

CALIFORNIA UNIV DAVIS

Personal Author(s):

Report Date:

2007-11-25

Pagination or Media Count:

17.0

Abstract:

Major histocompatibility complex MHC human leukocyte antigen HLA in humans plays significant role in mate selection and kin recognition mainly through apparition of organism specific odor recognized by other individuals. However a mechanism of the relationship between unique MHC genetic combination of an organism and generation of the specific organism odor is not understood. We are showing here that human B cells produce volatile organic odor compounds measurable by GCMS technique. More importantly, our results evidence that a presence of specific HLA allele in the cells is related to apparition of specific cell odor fingerprint. This work demonstrates for the first time that HLA influences production of specific odor.

Subject Categories:

  • Biochemistry
  • Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE