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Detection and Evaluation of Early Breast Cancer via Magnetic Resonance Imaging: Studies of Mouse Models and Clinical Implementation

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Annual summary rept. 6 Feb 2007-5 Feb 2008

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The general goals of this research are to i improve the specificity of MRI to early cancer, particularly ductal carcinoma in situ DCIS, by studying the MR presentation of early cancers compared with other malignant and benign lesions in women, ii to develop techniques for imaging DCIS and early invasive cancer in mice via MR imaging, and iii to use these techniques to study the progression of murine mammary cancer. The pre-clinical animal research proposed here can directly lead to clinical improvements in both early breast cancer detection, as well as effective breast cancer therapy. To date, we have performed a comprehensive evaluation of the MR kinetic and morphologic characteristics of DCIS and early invasive cancers compared with other lesions. We have also developed techniques to image early murine mammary cancer, including DCIS, using in vivo MRI. To our knowledge, this is the first report of the in vivo detection of murine DCIS with histopathologic correlation. We have also performed a longitudinal imaging experiment in 12 transgenic mice, following the development and progression of murine DCIS into invasive carcinoma. In this study we have found that some DCIS lesions have remained stable and did not progress to invasive cancer during the study window. These represent the first steps towards probing in vivo the radiologic and biologic changes that occur during the transition from in situ to invasive cancer.

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  • Medicine and Medical Research

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