Laminin-5 gamma2 Chain in Breast Cancer Metastasis
Annual summary rept. 1 Feb 2007-31 Jan 2008
VANDERBILT UNIV NASHVILLE TN
Pagination or Media Count:
Cancer cells have to break through basement membrane BM to metastasize. Laminin-5 is one of the major components of BM. It is composed of three chains alpha3, beta3 and gamma2. The DIII domain which could be released from Ln-5 gamma2 chain by MMPs processing, can bind to EGFR and activates the downstream signaling pathway. The role of Ln-5 in cancer progression is still unclear. There are paradoxical data in regard of the role of Ln-5 in cancer progression. Both increased and decreased expression levels of Ln-5 subchains are reported in the literature. The fact that gamma2 chain exists in two different forms as a secreted monomer, or as a part of the Ln-5 heterotrimer leads us to hypothesize that those two forms may play different roles in cancer progression. In this proposal we will determine whether Ln-5 gamma2 monomer is positively correlated with breast cancer tumorigenecity. We will also determine the role of Ln-5 gamma2 chain in cancer progression when it is in the context of Ln-5 heterotrimer.
- Medicine and Medical Research