The Role of SnoN and Ski in Mammary Epithelial Cell Transformation
Annual summary rept. 1 Jul 2004-1 Dec 2007
CALIFORNIA UNIV BERKELEY
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Ski and SnoN are members of Ski oncoprotein family. Overexpression of Ski or SnoN can induce transformation of chicken embryonic fibroblast. SkiSnoN is recently identified as a repressor of TGF signaling pathway which is an important tumor suppression pathway at the early stage of tumorigenesis. Higher level of SkiSnoN is found in transformed mammary epithelial cells. SkiSnoN might play a role in regulation of the transformation of mammary epithelial cell by antagonizing TGF signaling pathway. In my project, I try to explore the role of SkiSnoN in the transformation of mammary epithelial cells.
- Medicine and Medical Research