Analysis of Morphogenic Effect of hDAB21P on Prostate Cancer and Its Disease Correlation
Final rept. 1 Feb 2004-28 Jan 2008
TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER
Pagination or Media Count:
DAB2IP was identified to be a DOC-2DAB2 interactive protein from normal basal cell population of prostate. DAB2IP is a new member of RAS-GAP family that is known to modulate extracellular signal-elicited RAS pathways. In androgen-independent prostate cancer AIPCa, RAS activation is often detected while DAB2IP is down regulated due to epigenetic control such as DNA methylation and histone acetylation or methylation. Genetic variation of DAB2IP is associated with the risk of aggressive PCa. In DAB2IP-knock out mouse, prostate hyperplasia is also noticed. Biochemical studies demonstrate that DAB2IP has a similar function as PTEN to modulate cell survival and apoptosis by interacting with critical proteins involved in these pathways. Thus, DAB2IP is a homeostatic complex controlling cell growth, differentiation and survival of prostate epithelia.
- Medicine and Medical Research