Effects of Radiation on Proteasome Function in Prostate Cancer Cells
Annual summary rept. 15 Jan 2007-14 Jan 2008
CALIFORNIA UNIV LOS ANGELES
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The proposed research in this proposal is based on our observation that the 26S proteasome is a direct target of radiation. In our initial statement of work, we proposed experiments investigating association and release of PIPs from the 26S proteasome as well as to study structural changes of the proteasome in response to radiation. We further intended to clarify to which extend proteasome subunit expression is regulated at the transcriptional, and posttranslational level in response to ionizing radiation. The final goal is to investigate these changes using cutting edge proteomic tools to identify the radiation target within the proteasome in prostate cancer. The aims are unaltered from the original submission.
- Medicine and Medical Research