Accession Number:

ADA482585

Title:

Genetic Screening of Cells with Enhanced Antibody Production

Descriptive Note:

Final progress rept. 1 Jun 2005-31 Aug 2006

Corporate Author:

FUNCTIONAL GENETICS INC ROCKVILLE MD

Personal Author(s):

Report Date:

2007-01-22

Pagination or Media Count:

11.0

Abstract:

Here we report the progress made for grant No. W911NF-05-C-0059 between the entire funding period, 6105 and 83106. We have completed the study proposed to use Functional Genetics proprietary technology, Randon Homozygous Knock Out RHKO to increase antibody production from a production cell line, in this case CHO cells, as measured by Specific Productivity Rate SPR. We also identified 2 candidate RHKO genes that cause increased SPR. Finally, we report the validation of one of these two genes.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE