Genetic Screening of Cells with Enhanced Antibody Production
Final progress rept. 1 Jun 2005-31 Aug 2006
FUNCTIONAL GENETICS INC ROCKVILLE MD
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Here we report the progress made for grant No. W911NF-05-C-0059 between the entire funding period, 6105 and 83106. We have completed the study proposed to use Functional Genetics proprietary technology, Randon Homozygous Knock Out RHKO to increase antibody production from a production cell line, in this case CHO cells, as measured by Specific Productivity Rate SPR. We also identified 2 candidate RHKO genes that cause increased SPR. Finally, we report the validation of one of these two genes.
- Medicine and Medical Research