Accession Number:

ADA482572

Title:

Structural Studies on Intact Clostridium botulinum Neurotoxins Complexed with Inhibitors Leading to Drug Design

Descriptive Note:

Annual rept. 28 Jan 2007-27 Jan 2008

Corporate Author:

BROOKHAVEN NATIONAL LAB UPTON NY

Personal Author(s):

Report Date:

2008-02-01

Pagination or Media Count:

7.0

Abstract:

This is an annual report in no cost extension period. In this period we have identified several compounds via virtual screening. These compounds include small molecules transition state analogues and benzimidazoles. We have determined the crystal structure of BoNTE with the substrate tetra peptide containing the scissile bond.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE