Structural Studies on Intact Clostridium botulinum Neurotoxins Complexed with Inhibitors Leading to Drug Design
Annual rept. 28 Jan 2007-27 Jan 2008
BROOKHAVEN NATIONAL LAB UPTON NY
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This is an annual report in no cost extension period. In this period we have identified several compounds via virtual screening. These compounds include small molecules transition state analogues and benzimidazoles. We have determined the crystal structure of BoNTE with the substrate tetra peptide containing the scissile bond.