New Therapeutic Strategies for Antibiotic-Resistant Select Agents
Final rept. 15 May 2005-14 Nov 2007
NEBRASKA UNIV MEDICAL CENTER OMAHA
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The goal of this project was to establish the scientific basis for a new class of antibiotics that are needed to combat the development of resistance to currently available medications or the engineering of resistance into biological select agents. A multidisciplinary team of microbiologists, biochemists, molecular biologists and drug discovery experts was established to explore the hypothesis that disruption of bacterial primase activity will provide the basis for antimicrobial discovery and further, that the modular components of primase will provide for the discovery of broad- and narrow-spectrum antibiotics. The experimental model examined the functional activities of the Gram positive Staphylococcus aureus with the Gram negative E.