Role of MicroRNA Genes in Breast Cancer Progression
Final rept. 1 Aug 2005-31 Jul 2007
RUTGERS - THE STATE UNIV PISCATAWAY NJ
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In this proposal we asked if miRNA expression is altered as cells progress through the different stages of cancer. Through our microarray experiments we have shown that many miRNAs are differentially regulated as cells progress through cancer stages. A general trend in miRNA expression emerges from this work. As cells progress toward a metastatic state more miRNAs are down regulated rather than up regulated. This suggests that many cellular proteins are up regulated in these cells and this could be involved in promoting tumor growth. We propose that the mouse if a good model system for the study of breast cancer since several miRNAs are similarly regulated in both mouse and human. Finally we are beginning to gain insights into the mechanism of how miRNAs are involved in cell growth--studies show that some regulated miRNAs control cell death. The mis-regulation of cell death could allow cells to escape normal regulatory mechanisms for removing tumorous cells.
- Anatomy and Physiology
- Medicine and Medical Research