Accession Number:

ADA482238

Title:

Evaluation of Fibroblast Activation Protein-Alpha (FAP) as a Diagnostic Marker and Therapeutic Target in Prostate Cancer

Descriptive Note:

Annual rept. 14 Mar 2006-28 Jun 2007

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

Report Date:

2007-12-01

Pagination or Media Count:

21.0

Abstract:

Our goal is to evaluate FAP expression patterns and enzymatic activity in both normal prostate tissue and at various stages of oncogenic transformation i.e. PIA, PIN, Localized and Advanced Cancer to determine tumor stage in which FAP expression may play a role. A second objective is to exploit this expression in the treatment of prostate cancer by developing therapies targeted for activation by FAP. This will be accomplished by identifying selective peptide substrates for the proteolytic activity of FAP and coupling these peptides to a highly cytotoxic agent, thapsigargin, to generate prodrugs that are only activated in prostate tumors where FAP is expressed.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE