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Dietary Fat and Vitamin E in Prostate Cancer Risk Among African Americans and Africans: A Case-Control Study

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Final rept. 14 Jan 2002-13 Jan 2007

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A pilot study to investigate prostate cancer dietary risk factors was initiated at the Howard University Cancer Center, Washington DC, in 2000, and recruited study participants from rural Nigeria. In 2002 the scope of the study was expanded to include African-Americans and African migrants in the United States so as to investigate the role of dietary nutrients associated with increased prostate cancer risk fatty acids and antioxidants associated with reduced risk for prostate cancer vitamin E, and to study how the process of migration may impact exposure to dietary risk factors for this cancer. African-Americans and African migrants study participants were recruited from the Washington D.C. metropolitan area while Nigerians were recruited from two rural and two urban communities, the health centers situated there, and one referral hospital. IRB approvals were obtained both from Howard University and the University of Benin Teaching Hospital, Nigeria. In 2003 the PI moved to Meharry Medical College, and this grant was transferred from Howard University Cancer Center. New consent forms were developed and IRB approval were obtained from this institution. Nigerian participants continued to be recruited as in the past while African-American and African migrants were recruited from Nashville, TN. The study protocol, survey, and procedures remained the same. The main objective of the study is to locate prostate cancer cases and select community based controls who were from the same socio-economic status and age groups in both countries in a case-control design. The various demographic, medical history, dietary patterns, and nutrient levels will be compared between cases and controls to determine the fatty acid risk factors for prostate cancer among men of African ancestry in both countries. The specific nutrients of interest are fatty acids some of which have been proposed as risk factors for prostate carcinogenesis, and vitamin E, a protective antioxidant.

Subject Categories:

  • Medicine and Medical Research
  • Food, Food Service and Nutrition

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