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UCLA High Speed, High Volume Laboratory Network for Infectious Diseases

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Final rept. 16 Mar 2007-15 Mar 2008

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Background. Government agencies and expert panels have recognized the need for laboratories capable of analyzing tens of thousands of biological samples per day that have hundreds of times more capability than at present. ObjectivesHypothesis. This project aims to develop a new high speed high volume high-throughput laboratory capability that will be linked in a network and operated by several premier institutions. The automated networked capability will make us stronger against natural diseases and bioterrorist attacks. Specific Aims. With FY06 initial year Congressional appropriations high-throughput bioagent screening and genotyping systems with quality controls will be implemented first. These systems will be housed in laboratory space upgraded to BSL3-enhanced BSL3e containment that enables the flow of numerous samples containing highly pathologic avian influenza and other select agents dual-use. With FY07 available FY08 available and FY 09 anticipated Congressional appropriations automated culturing and phenotyping systems will be implemented next. Study Design. Because of current public health and national security threats influenza surveillance and analysis will be the initial focus. Over three years the project will be expanded to include other biothreat agents bacterial andor viral. Relevance. The combination of high-throughput and automated systems will enable processing of tens of thousands of samples and provide critical laboratory capacity. The overall project will facilitate rapid expansion to multiple networked sites.

Subject Categories:

  • Medicine and Medical Research

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