Accession Number:

ADA479315

Title:

Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-abdominal Adhesions, and Arterial Injuries

Descriptive Note:

Final rept. 24 Jan 2005-23 Mar 2008

Corporate Author:

CHILDREN'S HOSPITAL CORP BOSTON MA

Personal Author(s):

Report Date:

2008-04-01

Pagination or Media Count:

89.0

Abstract:

The three goals of this project are i to discover and develop novel drugs which could prevent or reverse the vascular leak syndrome ii to develop angiogenesis inhibitors which would inhibit post-operative abdominal adhesions and, iii to isolate endothelial progenitor cells from blood, capable of being expanded in vitro and applied to vascular grafts. Progress has been made in each category we have demonstrated that the widely used antibiotic, doxycyline, is a potent inhibitor of VEGF-induced vascular leak, and that a combination of Lodamin and doxycycline have additive effects and inhibit vascular leakage by greater than 80 we have established that sunitinib likely does prevent intra-abdominal postoperative adhesions in rabbits and, we have isolated and characterized mesenchymal progenitor cells MPCs from human adult bone marrow and from human cord blood showed expansion potential suitable for tissue engineering and tissue regeneration applications.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE