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Prostate Cancer Risk in Relation to IGF-1 and its Genetic Determinants: A Case Control Study Within the Cancer Prostate Sweden Project (CAPS)

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Final addendum rept. 1 May 2006-30 Apr 2007

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A large genetic association study was conducted to examine relationships of prostate cancer risk with polymorphic variation in a series of selected candidate genes that are involved in pathways determining the synthesis of IGF-I and IGF-binding proteins, as well as biological response to IGF-I. The study is being performed within a large Swedish case-control study CAPS . Progress report We have completed the selection of DNA and haplotype tagging SNPs to be analyzed for all candidate genes, and have completed about three quarters thirds of all genotyping assays for the prostate cancer cases and control subjects. We have completed analysis of complete genetic variation in the IGF1, IGFBP3, IGFBP1, IGFALS, SST, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5 and GHR genes, as well as selected polymorphisms in the GHRL and GHSR using the linked database, containing data on tumour grade, stage and serum PSA levels, for all prostate cancer cases. Plasma assays of IGF-I and IGFBP-3 were performed and statistical analysis between circulating plasma levels and SNPs as well as prognostic factors, has been completed. Evidence was identified for associations between SNPs in IGF1, IGFBP3 and SSTR5 and circulating plasma levels. Evidence for association between genetic variation in the IGF1 gene and prostate cancer risk was identified. Concerning the construction of the study databases, the plasma measures, the genetic component of our project and statistical analysis, we have completed the project relatively on schedule. The delay in the genotyping aspect of the project was mainly due non-receipt of funds, a substantial amount is remains outstanding at this time.

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  • Medicine and Medical Research

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