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Microlocalization and Quantitation of Risk Associated Elements in Gleason Graded Prostate Tissue
Final rept. 1 Mar 2003-28 Feb 2007
CALIFORNIA UNIV REGENTS LOS ANGELES
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Epidemiological studies show that B Se and Znreduce prostate cancer risk whereas Ca and Cd increase risk. The objective of this proposal was to determine the concentration and location of these elements in normal and tumor tissue. Specific aims included 1 preparation of Gleason graded prostate tissue 2 determination of tissue concentrations of B Ca Cd Se and Zn and 3 determination of tissue and cellular distribution of these elements using a NanoSIMS ion microscope at Lawrence Livermore National Laboratory LLNL. Specific aims I 2 were accomplished and showed that B was unique in its variability. Further study identified B as a chemopreventative agent and a clinical trial has been designed to determine if it lowers PSA level in men. Aim 3 was accomplished but future studies are needed to improve the resolution of intracellular mapping of the elements. The work on B provided important insights on how the movement of calcium from the endoplasmic reticulum into the cytoplasm can be modulated by chemopreventative agents to reduce cell proliferation. This finding opens new opportunities for cancer prevention and control.
APPROVED FOR PUBLIC RELEASE