Accession Number:

ADA478812

Title:

PCBs Alter Dopamine Mediated Function in Aging Workers

Descriptive Note:

Annual rept. 15 Dec 2006-14 Dec 2007

Corporate Author:

HEALTH RESEARCH INC RENSSELAER NY

Personal Author(s):

Report Date:

2008-01-01

Pagination or Media Count:

14.0

Abstract:

The major hypothesis is that prior occupational exposure to polychlorinated biphenyls PCBs results in decrements in neuropsychological and neurological performance and the number of dopamine DA terminals in the basal ganglia determined by -CIT SPECT imaging. At the conclusion of data collection 241 former capacitor workers have completed neuropsychological and neurological examinations, a comprehensive questionnaire, a blood draw to measure serum PCB and thyroid hormone concentrations, and a non-invasive test to determine bone-lead concentrations. This latter measure will allow us to control for exposure to lead--a potential confounder. 89 subjects have undergone brain imaging at the Institute for Neurodegenerative Disorders in New Haven, CT to determine the relationship between serum PCBs and the number of basal ganglia DA terminals. Serum PCB concentrations have been determined at Mt. Sinai School of Medicine and thyroid hormone concentrations have been determined at the Wadsworth Center. All data collection is complete data analysis and manuscript preparation continues. Secure electronic databases have been created for all data.

Subject Categories:

  • Medicine and Medical Research
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE