Mechanisms in Chronic Multisympton Illnesses
Annual rept. 1 Jul 2006-30 Sep 2007
MICHIGAN UNIV ANN ARBOR
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The overall objective of this cooperative agreement are to conduct research in pursuit of identifying the physiologic mechanisms responsible for the symptoms of pain, fatigue, and memory difficulties commonly seen in patients with Chronic Multisymptom Illnesses CMI i.e., fibromyalgia, chronic fatigue syndrome, Gulf War Illnesses, etc. to identify the risk factors for developing these syndromes as well as programs aimed at both preventing theses illnesses and treating established cases. These objectives will be achieved through multiple research studies using innovative, technologically advanced e.g., functional MRI and telemedicine methodologies in a multidisciplinary environment. Various studies will be conducted to explore all aspects of pain processing, the effects of exercise deprivation and sleep reduction on symptomatology, the ability of exercise andor cognitive behavioral therapies to alter patients locus of control for pain, the neurobiological mechanisms of acupuncture on analgesia, the presence of hypersensitivity to auditory stimuli, and the effectiveness of cognitive behavioral therapy delivered via telemedicine and the internet. These studies will be conducted on well-characterized cohorts of CMI subjects and healthy controls taken form our burgeoning subject registry. Research continues at the University of Michigan, Ann Arbor, MI and Avera Research Institute, Sioux Falls, SD.
- Anatomy and Physiology
- Medicine and Medical Research