Accession Number:

ADA478661

Title:

Small Molecule Activation of Procaspase-2 for the Selective Induction of Apoptotic Death in Breast Cancer Cells

Descriptive Note:

Revised final rept. 15 Jul 2006-14 Jul 2007

Corporate Author:

ILLINOIS UNIV CHAMPAIGN

Personal Author(s):

Report Date:

2007-08-01

Pagination or Media Count:

13.0

Abstract:

We have synthesized a library of compounds based on a previously identified procaspase-2 activator. These compounds were then tested for their ability to activate procaspase-2 in vitro. The results from these tests indicated that several of the compounds did indeed activate procaspase-2. Testing of these active compounds against a panel of enzymes then revealed, surprisingly, that the compounds are general enzyme activators. We have now explored this phenomena of general enzyme activation more thoroughly and have submitted a manuscript on the topic. The data and knowledge acquired through this work now allows us to move confidently to a high-throughput screen to identify truly specific procaspase-2 activators.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE