Subcellular Responses to Narrowband and Wideband Radiofrequency Radiation
Final technical rept. 15 Jun 2002-14 Dec 2007
OLD DOMINION UNIV RESEARCH FOUNDATION NORFOLK VA
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The interest in subcellular effects of radiofrequency radiation has led to the establishment of a Multidisciplinary University Research Initiative MURI with scientists from six academic institutions Old Dominion University, Eastern Virginia Medical School, Massachusetts Institute of Technology, Washington University, University of Wisconsin and University of Texas Health Science Center participating. The ODU-led MURI worked closely with its sister MURI, led by Purdue Calumet University. The research work in the ODU MURI has led to the establishment of a new field in the area of pulsed electric field interactions with cells and tissues Intracellular Electromanipulation - with important biomedical applications. In particular, the research has a led to a better understanding of the effect of nanosecond pulses on cellular and subcellular membranes through experimental and modeling results, b has revealed the effect of such pulses on cell functions, such as apoptosis and calcium release from internal stores, c has provided important information about nanosecond pulsed electric field effects on genes and proteins, d has demonstrated the use of nanopulses for the treatment of tumors and the activation of platelets for advanced wound healing, and e has opened the possibility of using antennas with intense electrical pulses in the subnanosecond range, instead of electrodes, for medical treatments.
- Medicine and Medical Research
- Electricity and Magnetism
- Radiofrequency Wave Propagation