Accession Number:

ADA478465

Title:

Modulation of TRAIL Cytotoxicity by Amiloride in Prostate Cancer

Descriptive Note:

Annual summary rept. 1 Nov 2004-31 Oct 2006

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

• Kim, Ki Mo
• Kim, Young-Ho

Report Date:

2006-11-01

Pagination or Media Count:

17.0

Abstract:

The challenge today is to develop a cytotoxic agent that selectively induces cytotoxicity in prostate cancer cells but avoids significant toxicity to the normal tissues. In this study, we will develop a novel strategy by using TRAIL in combination with amiloride.

Descriptors:

• *PROTEINS
• *THERAPY
• *ANTHOXANTHIN PIGMENTS
• *PROSTATE CANCER
• TISSUES(BIOLOGY)
• APOPTOSIS
• DRUGS
• CELLS(BIOLOGY)
• CYTOTOXINS
• LIGANDS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE