Use of Bifunctional Immunotherapeutic Agents to Target Breast Cancer
Annual rept. 30 Mar 2006-29 Jun 2007
WISCONSIN UNIV-MADISON DEPT OF CHEMISTRY
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Strategies to eradicate tumors have long been sought in the medical and scientific research communities. We envisioned that small molecules could be used to decorate the unwanted cells as foreign and evoke a potent immune response to destroy them. We then developed a bifunctional conjugate that contains two binding motifs one targets a receptor on the surface of cancer cells and the other interacts with naturally occurring human antibody. Through a series of proof-of-principle experiments, we demonstrated that this compound targets cells and can recruit antibodies simultaneously. Moreover, we obtained very promising in vitro cytotoxicity data illustrating that we can selectively target cancer cells over normal ones. These results have led our team to extend the concept into in vivo testing with an animal model however, this work is at its beginning stages.
- Medicine and Medical Research