Accession Number:

ADA473771

Title:

Selection of Protease Inhibitors to Prevent or Attenuate Inflammatory Processes

Descriptive Note:

Final rept.

Corporate Author:

TNO DEFENCE SECURITY AND SAFETY RIJSWIJK (NETHERLANDS)

Personal Author(s):

Report Date:

2007-08-01

Pagination or Media Count:

101.0

Abstract:

Inflammation is a coordinated response aimed at the protection of the host at the onset of infection. In this process, human and bacterial proteases play a critical role. The regulation of human proteases is carried out by pro- and anti-inflammatory signals. Deregulation of human metallopeptidases results in many pathological reactions such as microbial invasion or inflammatory tissue damage. Also bacterial proteases can influence the balance between pro- and anti-inflammatory signals and thus cause tissue damage. A disadvantage of selecting a bacterial protease inhibitor is that inflammation caused by other biowarfare agents like viruses or toxins can not be treated. It would be more appropriate to select human proteases which have a function in the coordinated response aimed at the protection of the host at the onset of an inflammatory response. The kallikrein-kinin system can modulate both the innate and adaptive immunity and could therefore represent a promising approach for the development of novel strategies to treat bacterial infections. Efforts in future research in which the blockade of kinin receptors only or in combination with other compounds might result in the development of treatment to protect the host at the onset of infection.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE