Gene-Gene and Gene-Environment Interactions in the Etiology of Breast Cancer
Final rept. 1 Jun 2002 31 May 2007
MEHARRY MEDICAL COLL NASHVILLE TN
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The purpose of this proposal is to evaluate gene-gene and gene-environment interactions in the etiology of breast cancer in two ongoing case-control studies, the Shanghai Breast Cancer Study SBCS and the Nashville breast health Study NBHS and in a proposed case-control study, the Breast Cancer in West Africa Study BCAWS. An allelic variant of UGT1A1 allele28 was identified as a risk factor for postmenopausal breast cancer in Chinese women. A proposal was submitted and funded for the BCAWS study through U54-CA9140801 Adunyah PI. Samples and surveys acquired from the BCAWS study are currently being analyzed.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research