The Nuclear Death Domain Protein p84N5; A Candidate Breast Cancer Susceptibility Gene
Final rept. 1 May 2003-30 Apr 2007
FOX CHASE CANCER CENTER PHILADELPHIA PA
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Efforts to identify genes that contribute to breast cancer lead to the discovery of the human TREX complex, a group of proteins that work together to accurately process and transport messenger RNAs from the nucleus to the cytoplasm in a cell. A member of this complex, referred to as p84N5 more recently named hTREX84 was found to be a culprit of aggressive human breast cancers. hTREX84 is expressed at very low levels in normal breast epithelial cells, but is highly expressed in breast tumors. hTREX84 expression correlates with tumor size and the metastatic state of the tumor progression. Inhibition of hTREX84 levels via RNAi approaches blocks breast tumor cell growth and causes the cells to die. Thus, hTREX84 appears to be a prognostic marker for determining the aggressiveness of breast cancer and may also be an ideal target for therapeutic drugs against breast cancer.
- Medicine and Medical Research