Accession Number:

ADA471503

Title:

The Role of Protein Elongation Factor eEF1A2 in Breast Cancer

Descriptive Note:

Final rept. 15 Aug 2003-14 Aug 2006

Corporate Author:

HAMILTON REGIONAL CANCER CENTRE (ONTARIO)

Personal Author(s):

Report Date:

2006-09-01

Pagination or Media Count:

94.0

Abstract:

The overall goal of the project is to explore the role of protein elongation factor eEF1A2 in breast tumor development and to determine whether eEF1A2 is a useful breast cancer prognostic factor. eEF1A2 is one of two members of the eEF1A family of proteins eEF1A1 and eEF1A2 that bind amino-acylated tRNA and facilitate their recruitment to the ribosome during protein translation elongation. We have identified eEF1A2 as a novel breast cancer oncogene. Supporting this idea are our observations that a eEF1A2 expression is increased in approximately 50 of human breast tumors b eEF1A2 protein expression is a prognostic marker for breast cancer survival c eEF1A2 enhances the growth rate of malignant breast cells d eEF1A2 inhibits anoikis e eEF1A1 activates the AktPKB serinethreonine kinase e siRNA that inactivate eEF1A2 and inhibit the in vitro growth of breast cell lines and f eEF1A2 expression causes rearrangement of the actin cytoskeleton. Taken together, our observations indicate that eEF1A2 is likely to play a causal role in the development of breast cancer and that it is a likely target for breast cancer therapy.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE