Genetic and Hormonal Risk Factors for Prostate Cancer in African-American Men
Final rept. 1 May 2003-30 Apr 2007
MICHIGAN UNIV ANN ARBOR
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African American men are at greater risk for developing and dying from prostate cancer compared to white men. This disparity is likely due to a number of factors including environmental and genetic factors. The Flint Mens Health Study FMHS was established in 1995 as a population-based case-control study of African American men aged 40-79 residing in Genesee County, Michigan. The initial sample consisted of 730 men who completed an in-home interview consisting of potential risk factors for prostate cancer medical history and demographic data. 431 men provided a blood sample and 369 men who were determined to be free of cancer completed a comprehensive urologic exam. Additionally, 119 cases of prostate cancer have been identified from the same population. Studies have suggested a role for hormones and genetics in cancer incidence. However, studies have been completed in white populations and results have been conflicting. The objective of this study is to more clearly delineate the potential roles of selected hormones and growth factors in prostate cancer development.
- Medicine and Medical Research