Accession Number:

ADA470936

Title:

Non-Invasive Monitoring for Optimization of Therapeutic Drug Delivery by Biodegradable Fiber to Prostate Tumor

Descriptive Note:

Annual rept. 1 Feb 2006-31 Jan 2007

Corporate Author:

TEXAS UNIV AT ARLINGTON

Personal Author(s):

Report Date:

2007-02-01

Pagination or Media Count:

30.0

Abstract:

Chemotherapeutic drugs delivered by systematic administration exhibit great toxicity patients have to endure suffering from frequent injection or low dose IV treatment. Thus controlled release and of these drugs and real-time monitoring of the effects of the drug can be an better treatment modality. The Hypotheses are 1 A near-infrared NIR imager can non-invasively monitor the vascular oxygenation and blood volumes in prostate tumors. 2 The dynamic response of prostate tumor oxygenation to the chronic drug delivery can serve as indicator for treatment prognosis. 3 The control of drug delivery rate will have a significant impact on the treatment prognosis. The specific aims of the of the project are 1 To design and implement a NIR spectroscopic imaging system. 2 To develop imaging of drug concentration and tumor oxygenation. 3 To control the delivery of drug using a novel implantable micropump IDDS.4 To study the relationship between drug release rate, tumor oxygen levels and therapeutic outcome. 5 To create appropriate cancer tumor animal models, that will guide the growth of cancer tumor in Copenhagen rats.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE