Accession Number:

ADA470920

Title:

Dietary Influences on Alpha-Methylacyl-CoA Racemase (AMACR) Expression in the Prostate

Descriptive Note:

Annual rept. 1 Apr 2006-30 Mar 2007

Corporate Author:

ILLINOIS UNIV AT CHICAGO

Report Date:

2007-04-01

Pagination or Media Count:

45.0

Abstract:

Alpha Methyl Acyl CoA Racemase AMACR, a peroxisomal and mitochondrial enzyme, is up regulated in majority of prostate cancers PCa. This enzyme is involved in the breakdown of phytanic pristanic acids, which are derived primarily through the ingestion of dairy and red meat products. There are no studies done so far that have examined the relationship of this enzyme with red meat and dairy intake and therefore PCa risk. The current research focuses on examining the relationships between AMACR expression in the prostate and phytanicpristanic acid levels in the blood and prostate. So far, ten patients with Pca have been recruited in the study. Research staff has been trained to obtain dietary information as well as process tissue and blood samples from participants. Protocols for processing biological samples have been established. Preliminary optimization of laboratory assays relevant to the study is being performed. The long term goal of this project is to better understand relationships between diet and AMACR expression and its implication in PCa risk. prostate cancer risk.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE