Accession Number:

ADA470893

Title:

Targeting MRS-Defined Dominant Intraprostatic Lesions with Inverse-Planned High Dose Rate Brachytherapy

Descriptive Note:

Final rept. 26 Jan 2004-25 Jan 2007

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Report Date:

2007-02-01

Pagination or Media Count:

42.0

Abstract:

During these three years we have obtained CHR approval December 2004from the three step process G.U. P.R.C. and C.H.R. committees at UCSF. D.O.D. CHR approval was finally obtained in December 2006. Patient enrollment will begin immediately after receiving UCSF-CHR re-confirmation. We have developed a deformable image registration method to improve the quality of registration of probe-in MRSI data for probe-out radiation treatment planning. A similarity index SI of 98.1 was obtained for rigid probe patient data. We have also obtained a class solution for the boost of DIL defined by MRIMRSI as well as for the sparing of organs at risk including bladder rectum urethra and penile bulb. Patients enrollment will be initiated shortly.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE