Identification, Characterization and Clinical Development of the New Generation of Breast Cancer Susceptibility Alleles
Annual rept. 1 Mar 2006-28 Feb 2007
INSTITUTE OF CANCER RESEARCH SURREY (UNITED KINGDOM) SECTION OF CANCER GENETICS
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Breast cancer is a common disease in women but the causes are still largely unknown. There is considerable evidence to suggest that genetic factors play an important role in causing breast cancer, but the genes involved in the majority of breast cancers are currently unknown. Our aim is to identify genetic factors that increase the chance of breast cancer occurring. We have collected clinical information and samples from over 1500 breast cancer families. We will compare the frequency of genetic factors in these cases with control women without breast cancer. Within the last year we have used this new strategy to identify three new breast cancer predisposition genes, ATM, BRIP1 and PALB2, that each confer a 2-3 fold risk of breast cancer and account for -3 of excess risk of breast cancer. We have also performed an experiment to evaluate 15,000 coding genetic variants in 864 breast cancer cases and 1498 controls and we are following up these results in additional cases.
- Medicine and Medical Research