Angiogenesis and Invasiveness in Prostate Cancer Detected with High Spectral and Spatial Resolution MRi
Final rept. 24 Dec 2001-23 Jun 2006
CHICAGO UNIV IL
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We propose to develop new MR methods to improve early and accurate detection of prostate cancer, and guide treatment of the cancer. Although conventional MRI has high sensitivity, its specificity has been disappointing. New more specific and sensitive MRI methods would have a significant impact on clinical management of prostate cancer. Previous work in this laboratory showed that high spectral and spatial resolution HiSS MRI improves image quality and detection of the effects of contrast agents. HiSS images can be acquired with clinically acceptable run times by using frequency resolved echo planar methods to obtain detailed spectra of the water and fat resonances associated with each image voxel. We will test the hypothesis that Contrast enhanced HiSS MRI increases sensitivity to angiogenesis and invasiveness of prostate cancer. As a result HiSS MRI can accurately distinguish metastatic from non-metastatic cancer based on detailed scans of the primary tumor.
- Medicine and Medical Research