Role of Polyamine Oxidase (PAOh1/SMO) in Human Breast Cancer
Annual summary rept. 22 Mar 2004-21 Mar 2007
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
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This report provides an update on the study of the role of polyamine oxidasePAOh1SMO, spermine oxidase in drug response of human breast cancer. Thecytotoxic effects of two novel polyamine analogue compounds, CGC-11144 and CGC- 11047 were evaluated in the human breast cancer cell lines MDA-MB-231, Hs578t,MCF-7, 468, and T47D. Additionally, the hypothesis that induction of spermine oxidase by pro-inflammatory agents plays a role in carcinogenesis was evaluated using a model system of exposure of MCF-10a human breast epithelial cells tocigarette smoke extract CSE.
- Anatomy and Physiology
- Medicine and Medical Research