Accession Number:

ADA470594

Title:

The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer

Descriptive Note:

Annual summary rept. 31 Mar 2006-30 Mar 2007

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

Report Date:

2007-04-01

Pagination or Media Count:

12.0

Abstract:

The tasks outlined in the Statement of Work for the first year of research on the action of ADAM9 isoforms in tumor-stromal interactions encompassed the creation of reagents to properly and thoroughly study the problem as well as preliminary work studying exogenous ADAM9 in a cell-based system. The major developments during this research period were preliminary data showing that the longer form of ADAM9 ADAM9-L enhances the migration of breast cancer cells and that this is dependent on its metalloprotease activity and the development of an ADAM9-Ssecreted form antibody which allows us to detect both isoforms endogenously allowing for the development of more rigorous models using siRNA and endogenous protein to more thoroughly test our hypothesis.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE