The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer
Annual summary rept. 31 Mar 2006-30 Mar 2007
BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA
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The tasks outlined in the Statement of Work for the first year of research on the action of ADAM9 isoforms in tumor-stromal interactions encompassed the creation of reagents to properly and thoroughly study the problem as well as preliminary work studying exogenous ADAM9 in a cell-based system. The major developments during this research period were preliminary data showing that the longer form of ADAM9 ADAM9-L enhances the migration of breast cancer cells and that this is dependent on its metalloprotease activity and the development of an ADAM9-Ssecreted form antibody which allows us to detect both isoforms endogenously allowing for the development of more rigorous models using siRNA and endogenous protein to more thoroughly test our hypothesis.
- Medicine and Medical Research