Accession Number:

ADA470578

Title:

Selenium Potentiates Chemotherapeutic Selectivity: Improving Efficacy and Reducing Toxicity

Descriptive Note:

Annual summary rept. 1 Apr 2006-31 Mar 2007

Corporate Author:

INDIANA UNIV AT INDIANAPOLIS SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2007-04-01

Pagination or Media Count:

15.0

Abstract:

The goal of the research is to evaluate the contribution of DNA repair to the protective effects of selenium in the context of chemotherapy. Specifically, the aims are to determine whether selenium-induced protection from DNA-damaging chemotherapeutics in vivo corresponds to reduced myelosuppression. Second, determine if selenium induced protection from chemotherapeutic toxicity corresponds to elevated DNA repair in vivo.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE