Polychlorinated Biphenyls, Organochlorines & PD Risk: A Case Control Study in Alaska
Annual rept. 1 Apr 2006-31 Mar 2007
PARKINSONS INST SUNNYVALE CA
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The intent of this research is to conduct a case control study of Parkinsons Disease PD among Alaska Natives to determine the association of exposure to polychlorinated biphenyl PCBs residues, organochlorine pesticides and methylmercury with PD. The hypothesis is that increased exposure to these compounds will be associated with an increased risk of PD. Exposure will be determine by direct measurement of serum levels, as these compounds are persistent in body tissues. In addition, lifelong exposure will be estimated by structured interview, including a dietary history with specific attention to intake of fish, marine mammals and wild game, known sources of bioconcentration of these environmentally persistent compounds. The project will be conducted in two phases. Phase 1 is a developmental period and is currently ongoing. During this time, the specific aspects of the study design are being established, detailed protocols are being developed, and the necessary approvals for the research are being obtained. Once Phase 1 is complete, Phase 2 will be initiated. During Phase 2 the study will be conducted.
- Medicine and Medical Research