Accession Number:

ADA470130

Title:

Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer

Descriptive Note:

Final rept. 7 Jan 2005-6 Jan 2007

Corporate Author:

BETH ISRAEL DEACONESS MEDICAL CENTER BOSTON MA

Personal Author(s):

Report Date:

2007-02-01

Pagination or Media Count:

27.0

Abstract:

The P582S C-T and A588T G-A polymorphisms in the Hypoxia-inducible factor-1alpha HIF-1alpha gene have been associated with enhanced stability of the protein and androgen-independent prostate cancer CaP. Methods We examined the association of these polymorphisms with CaP among 1,072 incident cases and 1,271 controls, and further explored their joint associations with various prediagnostic plasma hormone levels. Results The A588T polymorphism was too rare to provide meaningful conclusions and the P582S polymorphism was not associated with CaP. We observed a significant interaction of the P582S genotype with insulin-like growth factor binding protein IGFBP-3 in modifying CaP risk such that higher IGFBP-3 levels versus median were associated with a reduced risk only among men with the wildtype OR, 95 CI 0.74, 0.57-0.97 Pinteraction 0.01. Conclusions We found no association between these HIF-1alpha gene polymorphisms with CaP, but the interaction between the P582S polymorphism and the IGF axis merits further evaluation in mechanistic studies

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE