A Functional Genomic Analysis of NF1-Associated Learning Disabilities
Annual rept. 1 Feb 2006-31 Jan 2007
CALIFORNIA UNIV IRVINE
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Learning disabilities severely deteriorate the life of many NF1 patients. However, the pathogenic process for NF1-associated learning disabilities has not been fully understood and an effective therapy is not available. This study was proposed to identify genes that are dysregulated in the hippocampus of the Nf1- mouse model by DNA microarray analysis. Characterization of these NF1-affected genes will dramatically improve our understanding of the molecular pathogenesis underlying NF1-associated learning deficits. During the third year of the project, we have focused on determining the biological functions of NF1-affected genes. In addition, we also characterized the effect of lovastatin treatment on genomic expression of the NF1 hippocampus.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research